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JoVE Core

Pharmacology

Video textbook for undergraduate courses: Visualized concepts and experiments

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25 Chapters

250+ Videos

850+ Multiple Choice Questions

Table of Contents

Chapter 1

General Pharmacological Principles

14 Videos

18 Minutes

1:26

Drug Discovery: Overview

8.3K views

1:28

Preclinical Development: Overview

4.6K views

1:11

Clinical Trials: Overview

3.1K views

1:17

Drug Nomenclature

2.1K views

1:25

Drug Regulation

1.7K views

1:25

Drug Classes and Categories

2.2K views

1:25

Drug-Receptor Bonds

3.1K views

1:29

Drug-Receptor Interactions

5.5K views

1:22

Routes of Drug Administration: Overview

6.7K views

1:18

Routes of Drug Administration: Enteral

4.1K views

Routes of Drug Administration: Parenteral

1:25

Routes of Drug Administration: Parenteral

2.1K views

Additional Routes of Drug Administration

1:18

Additional Routes of Drug Administration

3.1K views

Prescription, Nonprescription and Orphan Drugs

1:02

Prescription, Nonprescription and Orphan Drugs

829 views

Factors Affecting Drug Response: Overview

1:21

Factors Affecting Drug Response: Overview

2.1K views

Chapter 2

Adverse Drug Effects and Chemical Toxicity

11 Videos

15 Minutes

1:19

Pharmacovigilance

961 views

1:17

Drug Dependence

1.1K views

1:27

Effects of Chemicals: Overview

1.3K views

1:36

Types of Toxins

1.9K views

1:26

Toxic Reactions: Overview

1.1K views

1:27

Allergic Drug Reactions

931 views

1:07

Teratogenicity

2.6K views

1:25

Mutagenicity and Carcinogenicity

1.3K views

1:17

Antidotes

739 views

Prevention of Further Absorption of Poison

1:14

Prevention of Further Absorption of Poison

906 views

1:26

Enhanced Elimination of Poison

566 views

Chapter 3

Pharmacokinetics

29 Videos

37 Minutes

1:10

Pharmacokinetics: Overview

6.7K views

Drug Absorption Mechanism: Passive Membrane Transport

1:23

Drug Absorption Mechanism: Passive Membrane Transport

4.3K views

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

1:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

4K views

Drug Absorption: Factors Affecting GI Absorption

1:19

Drug Absorption: Factors Affecting GI Absorption

4.2K views

1:13

Bioavailability: Overview

3K views

Factors Influencing Bioavailability: First-Pass Elimination

1:23

Factors Influencing Bioavailability: First-Pass Elimination

6.7K views

1:16

Bioequivalence: Overview

1.2K views

1:12

First Pass Effect

6K views

1:14

Time Course of Drug Effect

2.2K views

1:21

Drug Distribution: Tissue Binding

2.7K views

1:25

Physiological Barriers

3.7K views

Drug Distribution: Plasma Protein Binding

1:29

Drug Distribution: Plasma Protein Binding

6K views

Compartment Models: Single-Compartment Model

1:14

Compartment Models: Single-Compartment Model

2.4K views

Compartment Models: Two-Compartment Model

1:20

Compartment Models: Two-Compartment Model

5.8K views

Drug Distribution: Volume of Distribution

1:25

Drug Distribution: Volume of Distribution

5.4K views

1:16

Drug Biotransformation: Overview

2.5K views

1:17

Drug Metabolism: Phase I Reactions

3.4K views

1:14

Drug Metabolism: Phase II Reactions

4K views

Drug Elimination by Renal Route: Glomerular Filtration

1:17

Drug Elimination by Renal Route: Glomerular Filtration

5.8K views

Drug Elimination by Renal Route: Tubular Reabsorption

1:22

Drug Elimination by Renal Route: Tubular Reabsorption

3.5K views

Drug Elimination by Renal Route: Tubular Secretion

1:15

Drug Elimination by Renal Route: Tubular Secretion

2.5K views

Drug Elimination: The Concept of Clearance

1:06

Drug Elimination: The Concept of Clearance

2.9K views

1:23

Drug Elimination: Non-Renal Routes

2.4K views

1:17

Kinetics of Drug Elimination

3.5K views

1:05

Steady State Concentration

4.7K views

1:15

Drug Dosage Regimen: Overview

3.7K views

Rational Dosage Regimen: Maintenance Dose and Loading Dose

1:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

4.3K views

1:01

Dosage Regimen: Fixed Dose

2K views

1:30

Prodrugs

2.7K views

Chapter 4

Pharmacodynamics

19 Videos

26 Minutes

1:24

Principles of Drug Action

6.4K views

1:26

Targets for Drug Action: Overview

7.2K views

1:26

Signal Transduction: Overview

8.9K views

Transducer Mechanism: G Protein–Coupled Receptors

1:30

Transducer Mechanism: G Protein–Coupled Receptors

2.2K views

Ligand-Gated Ion Channel Receptor: Gating Mechanism

1:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.4K views

Transducer Mechanism: Enzyme-Linked Receptors

1:27

Transducer Mechanism: Enzyme-Linked Receptors

2.7K views

1:31

Transducer Mechanism: Nuclear Receptors

1.5K views

1:03

Dose-Response Relationship: Overview

3.3K views

Dose-Response Relationship: Potency and Efficacy

1:22

Dose-Response Relationship: Potency and Efficacy

4.8K views

Dose-Response Relationship: Selectivity and Specificity

1:25

Dose-Response Relationship: Selectivity and Specificity

7.4K views

1:13

Therapeutic Index

4.6K views

1:25

Drug-Receptor Interaction: Agonist

2.7K views

1:28

Drug-Receptor Interaction: Antagonist

3.2K views

1:30

Combined Effects of Drugs: Antagonism

9.1K views

1:27

Combined Effects of Drugs: Synergism

4.5K views

1:30

Spare Receptors

3.7K views

Quantitative Aspects of Drug-Receptor Interaction

1:30

Quantitative Aspects of Drug-Receptor Interaction

1.1K views

1:29

The Two-State Receptor Model

2.1K views

1:20

Desensitization and Tachyphylaxis

2K views

Chapter 5

Drugs Acting on Autonomic Nervous System: Cholinergic Agonists and Antagonists Agents

24 Videos

33 Minutes

1:26

Autonomic Nervous System: Overview

4.9K views

Neurochemical Transmission: Sites of Drug Action

1:26

Neurochemical Transmission: Sites of Drug Action

2.6K views

1:30

Classification of Neurotransmitters

3.2K views

1:23

Cholinergic Neurons: Neurotransmission

3.3K views

1:25

Cholinergic Receptors: Muscarinic

2.6K views

1:15

Cholinergic Receptors: Nicotinic

3.2K views

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

1:22

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

1.2K views

Direct-Acting Cholinergic Agonists: Pharmacokinetics

1:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

1.3K views

Direct-Acting Cholinergic Agonists: Pharmacological Actions

0:59

Direct-Acting Cholinergic Agonists: Pharmacological Actions

1.5K views

Direct-Acting Cholinergic Agonists: Therapeutic Uses

1:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

832 views

Cholinesterases: Distribution and Function

1:22

Cholinesterases: Distribution and Function

531 views

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

1:29

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

635 views

Indirect-Acting Cholinergic Agonists: Mechanism of Action

1:18

Indirect-Acting Cholinergic Agonists: Mechanism of Action

2K views

Indirect-Acting Cholinergic Agonists: Pharmacokinetics

1:22

Indirect-Acting Cholinergic Agonists: Pharmacokinetics

1.1K views

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

1:30

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

751 views

Anticholinesterase Agents: Poisoning and Treatment

1:26

Anticholinesterase Agents: Poisoning and Treatment

968 views

Myasthenia Gravis: Overview and Treatment

1:20

Myasthenia Gravis: Overview and Treatment

1.8K views

1:15

Myasthenia Gravis: Diagnostic Tests

1.2K views

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

1:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

2.3K views

Cholinergic Antagonists: Pharmacokinetics

1:24

Cholinergic Antagonists: Pharmacokinetics

542 views

Cholinergic Antagonists: Pharmacological Actions

1:28

Cholinergic Antagonists: Pharmacological Actions

1.2K views

Cholinergic Antagonists: Therapeutic Uses

1:26

Cholinergic Antagonists: Therapeutic Uses

809 views

Drugs Acting on Autonomic Ganglia: Stimulants

1:23

Drugs Acting on Autonomic Ganglia: Stimulants

1.4K views

Drugs Acting on Autonomic Ganglia: Blockers

1:28

Drugs Acting on Autonomic Ganglia: Blockers

1.1K views

Chapter 6

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

20 Videos

28 Minutes

1:27

Adrenergic Neurons: Neurotransmission

4K views

Adrenergic Receptors (Adrenoceptors): Classification

1:27

Adrenergic Receptors (Adrenoceptors): Classification

2.9K views

1:31

Adrenergic Receptors: ɑ Subtype

1.7K views

1:26

Adrenergic Receptors: β Subtype

1.9K views

Adrenergic Agonists: Direct-Acting Agents

1:30

Adrenergic Agonists: Direct-Acting Agents

1.7K views

Adrenergic Agonists: Indirect-Acting Agents

1:25

Adrenergic Agonists: Indirect-Acting Agents

1.8K views

Adrenergic Agonists: Mixed-Action Agents

1:28

Adrenergic Agonists: Mixed-Action Agents

818 views

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

1:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

3.2K views

Adrenergic Agonists: Therapeutic Classification

1:18

Adrenergic Agonists: Therapeutic Classification

910 views

1:30

Adrenergic Agonists: Therapeutic Uses

889 views

Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers

1:17

Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers

965 views

Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers

1:22

Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers

919 views

Adrenergic Antagonists: Chemistry and Classification of β-Receptor Blockers

1:25

Adrenergic Antagonists: Chemistry and Classification of β-Receptor Blockers

718 views

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

1:27

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

927 views

Adrenergic Antagonists: ɑ and β-Receptor Blockers

1:31

Adrenergic Antagonists: ɑ and β-Receptor Blockers

554 views

Drugs Affecting Neurotransmitter Synthesis

1:29

Drugs Affecting Neurotransmitter Synthesis

1.5K views

Drugs Affecting Neurotransmitter Release or Uptake

1:21

Drugs Affecting Neurotransmitter Release or Uptake

1.2K views

1:25

Glaucoma: Overview

696 views

1:27

Open Angle Glaucoma: Treatment

525 views

1:28

Angle Closure Glaucoma: Treatment

622 views

Chapter 7

Skeletal Muscle Relaxants

13 Videos

17 Minutes

1:29

Neuromuscular Junction And Blockade

3.4K views

Classification of Skeletal Muscle Relaxants

1:28

Classification of Skeletal Muscle Relaxants

2.6K views

Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action

1:17

Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action

2K views

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

1:27

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

499 views

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics

1:11

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics

511 views

Depolarizing Blockers: Mechanism of Action

1:28

Depolarizing Blockers: Mechanism of Action

1.7K views

1:19

Depolarizing Blockers: Pharmocokinetics

369 views

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

1:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

729 views

Skeletal Muscle Relaxants: Adverse Effects

1:21

Skeletal Muscle Relaxants: Adverse Effects

437 views

Skeletal Muscle Relaxants: Therapeutic Uses

1:31

Skeletal Muscle Relaxants: Therapeutic Uses

587 views

Spasmolytic Agents: Chemical Classification

1:29

Spasmolytic Agents: Chemical Classification

998 views

Peripherally and Centrally Acting Muscle Relaxants: A Comparison

1:09

Peripherally and Centrally Acting Muscle Relaxants: A Comparison

3.6K views

Centrally Acting Muscle Relaxants: Therapeutic Uses

1:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

800 views

Chapter 8

Local Anesthetics

10 Videos

13 Minutes

Local Anesthetics: Chemistry and Structure-Activity Relationship

1:27

Local Anesthetics: Chemistry and Structure-Activity Relationship

4.6K views

1:23

Local Anesthetics: Mechanism of Action

2.4K views

1:13

Local Anesthetics: Pharmacokinetics

834 views

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

914 views

Local Anesthetics: Common Agents and Their Applications

1:23

Local Anesthetics: Common Agents and Their Applications

513 views

1:12

Local Anesthetics: Adverse Effects

481 views

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

1:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

1.2K views

Local Anesthetics: Clinical Application as Spinal Anesthesia

1:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

731 views

Local Anesthetics: Clinical Application as Epidural Anesthesia

1:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

484 views

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

1:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

527 views

Chapter 9

Cardiovascular Drugs: Antihypertensive Drugs

12 Videos

16 Minutes

Cardiovascular Drugs: Classification based on Therapeutic Indications

1:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

3.1K views

Hypertension and Regulation of Blood Pressure

1:18

Hypertension and Regulation of Blood Pressure

2.2K views

Antihypertensive Drugs: Action of Diuretics

1:16

Antihypertensive Drugs: Action of Diuretics

841 views

Antihypertensive Drugs: Thiazide-Class Diuretics

1:15

Antihypertensive Drugs: Thiazide-Class Diuretics

816 views

Antihypertensive Drugs: Potassium-Sparing Diuretics

1:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

696 views

Antihypertensive Drugs: Action of β<sub>1</sub> Blockers

1:17

Antihypertensive Drugs: Action of β₁ Blockers

524 views

Antihypertensive Drugs: Types of β-Blockers

1:28

Antihypertensive Drugs: Types of β-Blockers

817 views

Antihypertensive Drugs: Action of Calcium Channel Blockers

1:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

679 views

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

1:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

785 views

Antihypertensive Drugs: Angiotensin II Receptor Blockers

1:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

831 views

Antihypertensive Drugs: Direct Renin Inhibitors

1:25

Antihypertensive Drugs: Direct Renin Inhibitors

762 views

1:23

Antihypertensive Drugs: Vasodilators

617 views

Chapter 10

Cardiovascular Drugs: Antiarrhythmic and Heart Failure Drugs

12 Videos

16 Minutes

Electrophysiology of Normal Cardiac Rhythm

1:19

Electrophysiology of Normal Cardiac Rhythm

6.7K views

1:28

Mechanism of Cardiac Arrhythmias

1K views

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

1:22

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

1.7K views

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

1:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

821 views

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

1:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

1.2K views

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

1:20

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

952 views

1:29

Pathophysiology of Cardiac Performance

775 views

1:17

Pathophysiology of Heart Failure

1.7K views

1:26

Heart Failure Drugs: Inotropic Agents

682 views

1:22

Heart Failure Drugs: Diuretics

454 views

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

487 views

1:22

Heart Failure Drugs: β-Blockers

415 views

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Better learning outcomes for students

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Real-world demonstrations of scientific live experiments in top university labs. Bringing theory to life and showcasing research use of scientific concepts.

‘I beg you to call the boy back, and not send that note,’ she said. ‘I hate to think of your doing that. It isn’t the act of——’ "Never mind, we must have a long talk. At present there is a verbal message for me; what is it?" "Do you think she'd come? She'd have gone to Ship Island if I had caught her." "Why should I deny it?" Leona said boldly. "My husband was murdered. He was slain by Dr. Gordon Bruce for the sake of his money." The reformed system of education was to be not only moral and religious but also severely scientific. The place given to mathematics as the foundation of a right intellectual training is most remarkable, and shows how truly Plato apprehended the conditions under which knowledge is acquired and enlarged. Here, as in other respects, he is, more even than Aristotle, the precursor of Auguste Comte. He arranges the mathematical sciences, so far as they then existed, in their logical order; and his remarks on the most general ideas suggested by astronomy read like a divination of rational mechanics. That a recommendation of such studies should be put into the mouth of Socrates is a striking incongruity. The older Plato grew the farther he seems to have advanced from the humanist to the naturalistic point of view; and, had he been willing to confess it, Hippias and Prodicus were the teachers with whom he finally found himself most in sympathy. And turned their savage life to civil ways; The one at the end accomplishing a graceful pirouette is me--I mean He made his calculation. Countless times his nerves had been pulled by sounds which turned out on second thought to be only the contracting of the hot metal, subjected to the sun all day, as the evening breeze robbed it of its warmth. As he had made Mrs. Campbell his confidante from the first, he told her about this too, now, and finished with the half-helpless, half-amused query as to what he should do. "It may be any length of time before she decides that she is old enough, and it never seems to occur to her that this state of things can't go on forever, that she is imposing upon you." "And the most serious part of it," he added after a while, "is that she does not love me." "Will the guerrillas begin shootin' at us as soon's we cross the river?" "But we didn't lose 'em in action, and to say so'd be a lie," answered Si, whose conscience had none of the easy elasticity of his partner's. "We could report 'em burnt up by lightnin','but we won't. They was lost by sheer, dumbed carelessness, that me and you and the boys should knowed better than to've allowed. That's all there is of it, and that's what I'm goin' to report, if I have to." The battery was one of the oldest and best in the army, and its "fire discipline" was superb. She felt her heart grow sick. If she had been happy for four hours, why, in God's name, had they not passed like four hours instead of like four minutes? "Unto the ends of the earth—Hastings. There's a friend of Ades there wot'll guide me into the Spirit's ways." HoME 大香蕉综合伊人91新人 ENTER NUMBET 0015www.yntbjt.com.cn
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